
Study suggests the womb may be key to breaking cycle of fat, diabetes
"Obese women who manage to shed excess pounds before becoming pregnant may be able to break the cycle of inherited weight problems and pass along better health to their children, a new study shows.
Researchers
found that children were less likely to become obese if their mothers
lost significant weight through obesity surgery before becoming
pregnant, according to an upcoming study in the Journal of Clinical
Endocrinology & Metabolism. The children with the surgically
slimmed mothers also looked to have a lower risk of heart disease and diabetes.
“We’ve
shown that when the mother loses weight prior to becoming pregnant, the
kid does not become obese,” said Dr. John Kral, study co-author and a
professor of surgery and medicine at the State University of New York
Downstate Medical Center in Brooklyn.
Other studies have shown that obese moms are more likely than slim women to have obese children, Kral said.
And
the health risks associated with obesity are well-documented for both
moms and babies, said Dr. Dominic Marchiano, an assistant professor of
obstetrics and gynecology at Pennsylvania Hospital in Philadelphia.
But until now, it was unclear exactly how to break the cycle.
Steeped in sugary womb
The
new results shift some of the blame for childhood obesity from genes
and the home environment to the conditions a fetus encounters as it
matures in the womb.
Factors in the uterus
might affect how a kid’s genes function later on, Kral said. For
example, obese mothers often have blood sugar levels that are too high.
“And that can leave the kid marinating in
sugar as he develops,” Kral said “But it’s not only that. There are
many other substances in the amniotic fluid of an obese woman that can
affect the developing offspring.”
Kral
and his colleagues studied 111 children from Quebec City, some of whom
were conceived before and some after their moms had weight-loss
surgery. The kids ranged in age from 2 to 26.
The 49 moms in the study had a procedure called biliopancreatic diversion, or BPD.
That
surgery directs food to bypass part of the small intestine and also
makes the stomach a little smaller. The resulting weight loss is mainly
due to the fact that people absorb fewer calories, Kral said, adding
that studies have shown that people with BPD continue to eat
significantly more than people who are naturally lean. This suggests
that what the moms ate later on, during their babies’ childhoods,
wasn’t the difference; instead, it was likely their actual weight loss.
The women in the study had lost an average
of 36 percent of their body weight and had kept the weight off for
about 12 years. They also had experienced improvement in their
cholesterol and blood sugar levels.
Kral
and his colleagues counseled the women to hold off on conceiving until
they had achieved their desired body weight. When the women did become
pregnant, they were given supplements to make sure that their babies
didn’t miss any important nutrients, Kral said.
Healthier babies
When
the researchers compared children conceived before and after a mom’s
weight loss surgery, they found startling results: post-surgery babies
were smaller, though not underweight, and they were three times less
likely to become severely obese as they grew up.
The
children born to thinner moms also appeared to be healthier overall,
with lower insulin resistance and cholesterol levels, signs of a
reduced risk of diabetes and heart disease.
And
these results were the same when the researchers limited their analysis
to children who were siblings: 25 of the 49 moms had children born both
before and after their surgeries.
What was most striking, Kral said, was that you could break a family’s cycle of obesity by getting the mom to lose weight.
Further,
Kral said, it really doesn’t matter how the moms drop the pounds. The
results are expected to be the same if a mom loses weight through
dieting instead of surgery.
These new
results may give those contemplating pregnancy another incentive to
slim down, Marchiano said. “We always recommend that women lose weight
prior to conception — but not while they are pregnant,” he added. “This
may help with motivation as women think about the weight destiny of
their children.”
URL: http://www.msnbc.msn.com/id/32692882/ns/health-diabetes/
Full article at MSNBC
I especially like the visual of the fetus marinating in sugar.
I'm actually an experiment in progress, with three pre-WLS babies and one post WLS baby.
Does the post WLS kid stand a better chance of not becoming obese? Environment be damned, will she be better off than the first three? I do wonder sometimes.
My post WLS child didn't marinate in sugar, in fact, I was seriously hypoglycemic throughout her development. I actually wondered if she would be negatively effected due to my health post WLS. For a while, I thought she might be born with some type of abnormality, either from the constant hypoglycemia, anemia or another vitamin issue. She, of course, is now nearly three and fine, but I did wonder!
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