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Fexaramine Tricks Mice Into Losing Weight Without Food?!

Lose weight without worrying about food? Imagine this?!

Via Popular Science "Safe and effective weight loss doesn't yet come in a pill, but maybe one day it will. A new study has found a chemical that keeps mice from gaining weight through overeating. The drug also seemed to protect lab mice from some of the harmful effects of obesity: When researchers measured the mice's blood, they found reduced levels of insulin, cholesterol, and other molecules, compared to obese mice who didn't get the drug."

'Imaginary meal' tricks the body into losing weight - Salk Institute - News Release.

“This pill is like an imaginary meal,” says Ronald Evans, director of Salk’s Gene Expression Laboratoryand senior author of the new paper, published January 5, 2014 in Nature Medicine. “It sends out the same signals that normally happen when you eat a lot of food, so the body starts clearing out space to store it. But there are no calories and no change in appetite.”

In the United States, more than a third of adults are obese and 29.1 million people have diabetes, according to the Centers for Disease Control and Prevention. Both obesity and diabetes lead to an increase in health spending, a greater risk of health complications and a shorter lifespan.


Study -

Recommended Carbohydrate Levels After Gastric Bypass

Via Bariatric Times -


After you read this study, let's discuss:  

  • Did your nutritionist give YOU guidance in regards to carbohydrate intake after your roux en y gastric bypass surgery?
  • Background: Exact carbohydrate levels needed for the bariatric patient population have not yet been defined. The aim of this study was to correlate carbohydrate intake to percent excess weight loss for the bariatric patient population based on a cross-sectional study. The author also aimed to review the related literature.
  • Materials and Methods: A cross-sectional study was conducted, along with a review of the literature, about patients who underwent Roux-en-Y gastric bypass at least 1 year previously. Patients had their percentage of excess weight loss calculated and energy intake was examined based on data collected with a four-day food recall. Patients were divided into two groups: 1) patients who consumed 130g/day or more of carbohydrates and 2) patients who consumed less than 130g/day of carbohydrates. 
  • Limitations: The literature review was limited to papers published since 1993. 
  • Results: Patients who consumed 130g/day or more of carbohydrates presented a lower percent excess weight loss than the other group (p= 0.038). In the review of the literature, the author found that six months after surgery patients can ingest about 850kcal/day of carbohydrates, 30 percent being ingested as lipids. A protein diet with at least 60g/day is needed. On this basis, patients should consume about 90g/day of carbohydrates. After the first postoperative year, energy intake is about 1,300kcal/day and protein consumption should be increased. We can, therefore, establish nearly 130g/day of carbohydrates (40% of their energy intake) 
  • Conclusions: Based on these studies, the author recommends that 90g/day is adequate for patients who are six months post Roux-en-Y gastric bypass and less than 130g/day is adequate for patients who are one year or more post surgery. 
  • The author concludes that maintaining carbohydrate consumption to moderate quantities and adequate protein intake seems to be fundamental to ensure the benefits from bariatric surgery.


What does 2000 calories look like!?

I might be slightly disturbed by this, and it is blatantly obvious why I was 320 lbs, and even more clear How Easy It Is To Regain Weight After Bariatric Surgery.

Just a few calories a day - it adds up so damned fast.

My before-WLS diet would easily dwarf this 2000-calorie business.  

Related articles

How much water should I drink? #adultdiapersarehawt

How much water should I drink?  

Aren't we all supposed to have eight glasses of water a day?  

Or is it one ounce per pound of body weight?  HELP!  

I see water challenges on social media sites constantly -- I never know what their purpose was for -- considering they look a lot like this:  "EVERYONE STOP WHAT YOU ARE DOING AND TAKE A DRINK OF WATER ---------- GOOD --------- NOW PEE!"  

I never caught on.  


Huffington Post -

How much water am I meant to drink? Is it really eight cups a day?

The notion that we must all drink eight cups of water per day to improve our health is an old one, but it isn't exactly accurate. Although the suggestion dates back to at least the 1940s, the latest to carry the mantel are, unsurprisingly, bottled water companies.

Writing in the medical journal BMJ, Glasgow doctor Margaret McCartney pointed out that much of the current recommendations come from events sponsored by Danonewhich owns bottled water lines Evian, Volvic and Badoit.

The "8x8 advice" may also endure because, cost aside, it's harmless. And being over-hydrated sure beats dehydration, which can cause headaches, light-headedness, fatigue and other, more serious complaints. Water is essential for proper digestion, kidney function and brain function and is required by every cell of the body. But that doesn't mean we need to sip on it all day.

There may be another reason we've stuck with an inaccurate eight cups -- and that answer isn't nearly so straight forward: the right amount of water to drink is the amount that quenches your thirst.

"When you think about the way that the body handles water, you pee it out. The body regulates water very carefully and doesn't allow it to accumulate. Extra water is immediately excreted," says Dr. Stanley Goldfarb, a professor of medicine at University of Pennsylvania and an expert on fluid management.

What's more, our bodies tell us when we require water -- that's what the thirst mechanism does. Thirst doesn't mean you've reached a dire level of dehydration either. Explains Goldfarb: "When you get thirsty, the deficit of water in your body is trivial -- it's a very sensitive gauge. It might be only a one percent reduction in your overall water. And it just requires drinking some fluid."

Or food: about 20 percent of the fluid we receive each day comes from water-heavy foods like fruits and vegetables.

There is, however, one exception: for those who suffer from kidney stones -- masses of crystals that form in the urine and pass painfully through the urethra -- staying overly hydrated is very beneficial, as it dilutes the concentration of material that forms into the clumps.

The typical U.S. adult downs about four cups a day, which is shy of the Institute of Medicine's recommendation to drink about three liters of fluid for men and 2.2 liters for women. But others disagree with this assessment -- if that's the amount of water a person naturally drinks in response to thirst, that's fine. But there is no benefit to forcing extra water.

Just to reiterate, we're talking exclusively about over-hydration. Beware dehydrating factors like exercise, salty foods and hot weather, and be sure to replace the fluid you've lost. A surefire way to tell if you've replaced your water sufficiently? It's all in your urine. If you're producing pale yellow pee, you've reached a hydrated status.

You can keep drinking, but why?


Colonoscopy Preparation is FUN!

In twenty-four hours I will be in my hospital's Gastrointestinal Unit waiting room, awaiting the joy that is a colonoscopy.  Please note that the MM Sarcasm is currently dialed up to high.  Nobody really looks forward to tests, and for a test that involves forcing a camera up your arse, I'd better be a little silly about it or I'll whine.

Continue reading "Colonoscopy Preparation is FUN!" »